Article

Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics

2025-10-31

Abstract excerpt

That males and females age differently has been overlooked while developing aging clocks. Here, we developed a sex-specific metabolic aging clock in 390,941 individuals from the UK Biobank and integrated it with genetic, proteomic and epidemiological data to identify mechanisms accelerating/decelerating metabolic aging in males and females. Our findings reveal dysregulation of cholesterol metabolism, immune system...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02b63f3c-2448-5b0a-845e-0be8d5471e14
DOI: 10.1101/2025.10.30.25339071

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and GenomicsDOI 10.1101/2025.10.30.25339071Read

Multiomics insights into the female reproductive agingSemantic proximity Read

Determining a multimodal aging clock in a cohort of Chinese women.Semantic proximity Read

Multiomics of Aging and Aging-Related Diseases.Semantic proximity Read

Heterogeneous metabolomic aging across the same age and prediction of health outcomeSemantic proximity Read

Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality riskSemantic proximity Read

Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity-related morbidities.Semantic proximity Read

Tuning up an aged clock: Circadian clock regulation in metabolism and agingSemantic proximity Read

Nonlinear dynamics of multi-omics profiles during human agingSemantic proximity Read

Specific differences and novel key regulatory genes of sex in influencing exceptional longevity phenotypes.Semantic proximity Read

Plasma acylcarnitines and gut‐derived aromatic amino acids as sex‐specific hub metabolites of the human aging metabolomeSemantic proximity Read

Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk.Semantic proximity Read

Multi-omic underpinnings of epigenetic aging and human longevity.Semantic proximity Read