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Article

A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study.

PloS one - 1 Jan 2024

Liu Hengzhi, Fan Yi, Liang Jie, Hu Aixin, Chen Wutong, Wang Hua, Fan Yifeng, Li Mingwu, Duan Jun, Wang Qinzhi

Abstract excerpt

OBJECTIVE: Sarcopenia and cognitive impairment often coexist in the elderly. In this study, we investigated the causal relationship between sarcopenia-related muscle characteristics and cognitive performance. METHODS: We used linkage disequilibrium score regression (LDSC) and Mendelian Randomization (MR) analyses to estimate genetic correlations and causal relationships between genetically predicted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39240885
DOI: 10.1371/journal.pone.0309124
PMCID: PMC11379137

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