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Analysis of androgen receptor expression and activity in the mouse brain

15 May 2024

Abstract excerpt

Androgen deprivation therapy (ADT) is the core treatment for advanced prostate cancer (PCa), with a proven survival benefit. ADT lowers circulating testosterone levels throughout the body, but with it comes a variety of reported side effects including fatigue, muscle wastage, weight gain, hot flushes and importantly cognitive impairment, depression, and mood swings. Testosterone has a key role in brain...

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PMID: 38750183
DOI: 10.1038/s41598-024-61733-9

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