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Article

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review]

1 Jan 2017

Abstract excerpt

Hormonal alterations with aging contribute to the pathogenesis of several diseases. Androgens mediate their effects predominantly through binding to the androgen receptor (AR), a member of the ligand-dependent nuclear receptor superfamily. By androgen treatment, AR is recruited to specific genomic loci dependent on tissue specific pioneer factors to regulate target gene expression. Recent studies have revealed...

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PMID: 28824023
DOI: 10.1507/endocrj.ej17-0328

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