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Article

Loss-of-function FLG mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London.

Clinical and experimental dermatology - 22 Nov 2024

Hughes Aaron J, Barbosa Elsa, Cernova Jeva, Thomas Bjorn R, O'Shaughnessy Ryan F L, O'Toole Edel A

Abstract excerpt

BACKGROUND: Acne vulgaris (AV) is the eighth most common nonfatal disease globally. Previous work identified an association between AV and increased filaggrin (FLG) protein expression in the follicular epidermis, but further work did not find a clear link between loss-of-function (LoF) FLG gene mutations and protection from AV. OBJECTIVES: To explore any association between AV and FLG LoF mutations in a cohort of...

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PMID: 38747172
DOI: 10.1093/ced/llae185

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