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Article

Induction of diabetes by Tacrolimus in a phenotypic model of obesity and metabolic syndrome.

Frontiers in endocrinology - 1 Jan 2024

Teixidó-Trujillo Silvia, Porrini Esteban, Menéndez-Quintanal Luis Manuel, Torres-Ramírez Armando, Fumero Cecilia, Rodríguez-Rodríguez Ana Elena

Abstract excerpt

Introduction: The pathogenesis of Post-Transplant Diabetes Mellitus (PTDM) is complex and multifactorial and it resembles that of Type-2 Diabetes Mellitus (T2DM). One risk factor specific to PTDM differentiates both entities: the use of immunosuppressive therapy. Specifically, Tacrolimus interacts with obesity and insulin resistance (IR) in accelerating the onset of PTDM. In a genotypic model of IR, the obese...

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Share to Diabetes Mellitus, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rats, Sprague-Dawley

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Identifiers

PMID: 38745946
DOI: 10.3389/fendo.2024.1388361
PMCID: PMC11092379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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