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Article

Tacrolimus and sirolimus induce reproductive abnormalities in female rats.

Transplantation - 27 Jun 2011

Shivaswamy Vijay, Ochsner Luann, Maroni Dulce, Wang Cheng, Passer Joel, Clure Cara E, Hamel Frederick G, Davis John S, Larsen Jennifer

Abstract excerpt

BACKGROUND: Immunosuppression medications contribute to posttransplant diabetes mellitus in patients and can cause insulin resistance in male rats. Tacrolimus (TAC)-sirolimus (SIR) immunosuppression is also associated with appearance of ovarian cysts in transplant patients. Because insulin resistance is observed in patients with polycystic ovary syndrome, we hypothesized that TAC or SIR may induce reproductive...

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Identifiers

PMID: 21508897
DOI: 10.1097/TP.0b013e31821c1e8b
PMCID: PMC5606232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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