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Article

Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection.

Breast cancer research : BCR - 14 May 2024

Raj-Kumar Praveen-Kumar, Lin Xiaoying, Liu Tao, Sturtz Lori A, Gritsenko Marina A, Petyuk Vladislav A, Sagendorf Tyler J, Deyarmin Brenda, Liu Jianfang, Praveen-Kumar Anupama, Wang Guisong, McDermott Jason E, Shukla Anil K, Moore Ronald J, Monroe Matthew E, Webb-Robertson Bobbie-Jo M, Hooke Jeffrey A, Fantacone-Campbell Leigh, Mostoller Brad, Kvecher Leonid, Kane Jennifer, Melley Jennifer, Somiari Stella, Soon-Shiong Patrick, Smith Richard D, Mural Richard J, Rodland Karin D, Shriver Craig D, Kovatich Albert J, Hu Hai

Abstract excerpt

BACKGROUND: Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non-luminal A tumors, classified as difficult-to-treat breast cancers (DTBC). This study aims to delineate the proteogenomic landscape of DTBC tumors compared to luminal A (LumA) tumors. METHODS: We...

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Identifiers

PMID: 38745208
DOI: 10.1186/s13058-024-01835-4
PMCID: PMC11094977

Genes

ARID1A
CDH1
DCK
FOXO3
MYO9B
PIK3CA
PLXNB3
PTEN
RBM14
SDC2
SVIL
TP53
ZC3HAV1

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