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Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes

16 Feb 2022

Abstract excerpt

Despite advances in genomic classification of breast cancer, current clinical tests and treatment decisions are commonly based on protein level information. Formalin-fixed paraffin-embedded (FFPE) tissue specimens with extended clinical outcomes are widely available. Here, we perform comprehensive proteomic profiling of 300 FFPE breast cancer surgical specimens, 75 of each PAM50 subtype, from patients diagnosed...

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PMID: 35173148
DOI: 10.1038/s41467-022-28524-0

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