Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress.

Abstract excerpt

Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; however, their degradation can result in certain metabolic stresses. Their breakdown can generate propionyl-CoA, which gives rise to potentially toxic intermediates. Detoxification of propionyl-CoA relies on the activity of...

Topics

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• Acetyl Coenzyme A
• Acyl Coenzyme A
• Cholesterol
• Fatty Acids
• Host-Pathogen Interactions