Efficient and reproducible generation of human induced pluripotent stem cell-derived expandable liver organoids for disease modeling

Abstract excerpt

Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems. Previously, we developed novel proliferative and functional liver organoids from pluripotent stem cells; however, the protocol requires improvement for standardization and reproducible mass production. Here, we improved the method such that it is suitable for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic and Kidney Cyst Diseases
• Share to Liver physiology and pathology
• Share to Pancreatic function and diabetes