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Article

Structure of the SARS-CoV-2 Frameshift Stimulatory Element with an Upstream Multibranch Loop

10 May 2024

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshift stimulatory element (FSE) is necessary for programmed -1 ribosomal frameshifting (-1 PRF) and optimized viral efficacy. The FSE has an abundance of context-dependent alternate conformations, but two of the structures most crucial to -1 PRF are an attenuator hairpin and a three-stem H-type pseudoknot structure. A crystal structure of the...

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PMID: 38727003
DOI: 10.1021/acs.biochem.3c00716

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