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Article

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats.

The journal of headache and pain - 10 May 2024

Alpay Berkay, Cimen Bariscan, Akaydin Elif, Onat Filiz, Bolay Hayrunnisa, Sara Yildirim

Abstract excerpt

BACKGROUND: GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors. The role of extrasynaptic GABAergic input in migraine is unknown. We investigated the susceptibility to valid migraine-provoking substances with clinically relevant...

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Disease Models, Animal
Epilepsy, Absence
Hyperalgesia
Migraine Disorders
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, GABA-A

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Identifiers

PMID: 38724972
DOI: 10.1186/s10194-024-01777-4
PMCID: PMC11083752

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