Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization.

The journal of headache and pain - 24 Jul 2023

Alpay Berkay, Cimen Bariscan, Akaydin Elif, Bolay Hayrunnisa, Sara Yildirim

Abstract excerpt

BACKGROUND: Migraine headache attacks and accompanying sensory augmentation can be induced by several agents including levcromakalim (LVC), that is also capable of provoking aura-like symptoms in migraineurs. We investigated whether single LVC injection causes acute migraine-like phenotype in rats and induces/modulates cortical spreading depolarization (CSD), a rodent model of migraine aura. METHODS: Wistar rats...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Cortex
Share to Migraine Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Rats, Wistar

Source

Open in PubMed Open full text

Identifiers

PMID: 37488480
DOI: 10.1186/s10194-023-01627-9
PMCID: PMC10367339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization.PMID 37488480Read ↗

GAERS are resistant to migraine-provoking agents: The role of extrasynaptic GABAA receptorsSemantic proximity Read ↗

Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant miceSemantic proximity Read ↗

Migraine: new molecular mechanisms.Semantic proximity Read ↗

A c-Fos activation map in NTG/levcromakalim-induced chronic migraine miceSemantic proximity Read ↗

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats.Semantic proximity Read ↗

[Migraine--mechanisms and consequences for treatment].Semantic proximity Read ↗

[Migraine: clinical aspects, diagnosis and pharmacotherapy].Semantic proximity Read ↗

FKN/CX3CR1 Axis Facilitated Migraine-like Behaviors via Activating Thalamic-cortical Network Microglia in SE Rat ModelsSemantic proximity Read ↗

Cortical Spreading Depression Can Be Triggered by Sensory Stimulation in Primed Wild Type Mouse Brain: a Mechanistic Insight to Migraine Aura GenerationSemantic proximity Read ↗

Spreading depression and the clinical correlates of migraine.Semantic proximity Read ↗

Phenotypic features of chronic migraine.Semantic proximity Read ↗

Pathogenesis and Preventive Pharmacotherapy of Migraine Aura: A Critical Review of Cortical Spreading Depolarization Mechanisms, Drug Repurposing Evidence, and the Emerging Therapeutic PipelineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.