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Article

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma

9 May 2024

Abstract excerpt

Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene...

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PMID: 38724552
DOI: 10.1038/s41467-024-48034-5

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