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Article

Trim66's paternal deficiency causes intrauterine overgrowth.

Life science alliance - 1 Jul 2024

Mielnicka Monika, Tabaro Francesco, Sureka Rahul, Acurzio Basilia, Paoletti Renata, Scavizzi Ferdinando, Raspa Marcello, Crevenna Alvaro H, Lapouge Karine, Remans Kim, Boulard Matthieu

Abstract excerpt

The tripartite motif-containing protein 66 (TRIM66, also known as TIF1-delta) is a PHD-Bromo-containing protein primarily expressed in post-meiotic male germ cells known as spermatids. Biophysical assays showed that the TRIM66 PHD-Bromodomain binds to H3 N-terminus only when lysine 4 is unmethylated. We addressed TRIM66's role in reproduction by loss-of-function genetics in the mouse. Males homozygous for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38719749
DOI: 10.26508/lsa.202302512
PMCID: PMC11077763

Genes

TRIM66

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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