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Plasma mtDNA as a possible contributor to and biomarker of inflammation in rheumatoid arthritis

7 May 2024

Abstract excerpt

OBJECTIVES: Neutrophil extracellular trap formation and cell-free DNA (cfDNA) contribute to the inflammation in rheumatoid arthritis (RA), but it is unknown if mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) is more abundant in the circulation. It is unclear if DNA concentration measurements may assist in clinical decision-making. METHODS: This single-center prospective observational study collected plasma from...

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Share to Blood disorders and treatments
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 38715082
DOI: 10.1186/s13075-024-03329-2

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