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Article

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice.

Endocrinology - 1 Dec 2008

Gelling Richard W, Yan Wenbo, Al-Noori Salwa, Pardini Aaron, Morton Gregory J, Ogimoto Kayoko, Schwartz Michael W, Dempsey Peter J

Abstract excerpt

Energy homeostasis involves central nervous system integration of afferent inputs that coordinately regulate food intake and energy expenditure. Here, we report that adult homozygous TNFalpha converting enzyme (TACE)-deficient mice exhibit one of the most dramatic examples of hypermetabolism yet reported in a rodent system. Because this effect is not matched by increased food intake, mice lacking TACE exhibit a...

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Identifiers

PMID: 18687778
DOI: 10.1210/en.2008-0775
PMCID: PMC2734496

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ADAM17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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