Co-occurring BRCA2/SPOP Mutations Predict Exceptional Poly (ADP-ribose) Polymerase Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer.

doi:10.1016/j.euo.2023.11.014

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Article

Co-occurring BRCA2/SPOP Mutations Predict Exceptional Poly (ADP-ribose) Polymerase Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer.

European urology oncology - 1 Aug 2024

Orme Jacob J, Taza Fadi, De Sarkar Navonil, Tewari Alok K, Arsalan Naqvi Syed, Riaz Irbaz B, Childs Daniel S, Omar Noha, Adra Nabil, Ashkar Ryan, Cheng Heather H, Schweizer Michael T, Sokolova Alexandra O, Agarwal Neeraj, Barata Pedro, Sartor Oliver, Bastos Diogo, Smaletz Oren, Berchuck Jacob E, McClure Heather, Taplin Mary-Ellen, Aggarwal Rahul, Sternberg Cora N, Vlachostergios Panagiotis J, Alva Ajjai S, Mehra Niven, Nelson Peter S, Hwang Justin, Dehm Scott M, Shi Qian, Fleischmann Zoe, Sokol Ethan S, Elliott Andrew, Huang Haojie, Bryce Alan, Marshall Catherine H, Antonarakis Emmanuel S

Abstract excerpt

BACKGROUND AND OBJECTIVE: BRCA2 mutations in metastatic castration-resistant prostate cancer (mCRPC) confer sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors. However, additional factors predicting PARP inhibitor efficacy in mCRPC are needed. Preclinical studies support a relationship between speckle-type POZ protein (SPOP) inactivation and PARP inhibitor sensitivity. We hypothesized that SPOP...

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PMID: 38072760
DOI: 10.1016/j.euo.2023.11.014
PMCID: PMC11162506

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