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Article

Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer.

European urology - 1 Nov 2020

Swami Umang, Isaacsson Velho Pedro, Nussenzveig Roberto, Chipman Jonathan, Sacristan Santos Victor, Erickson Stephanie, Dharmaraj Divya, Alva Ajjai Shivaram, Vaishampayan Ulka N, Esther John, Hahn Andrew W, Maughan Benjamin Louis, Antonarakis Emmanuel S, Agarwal Neeraj

Abstract excerpt

Recently, mutations in speckle-type pox virus and zinc finger protein (SPOP) gene (mutant SPOP [mtSPOP]) have been associated with improved outcomes to abiraterone in the castration-resistant setting. We hypothesized that mtSPOP would be associated with improved outcomes to systemic therapy in men with de novo metastatic castration-sensitive prostate cancer (d-mCSPC). Retrospective data of newly diagnosed d-mCSPC...

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Identifiers

PMID: 32624276
DOI: 10.1016/j.eururo.2020.06.033
PMCID: PMC7572891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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