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Article

Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss.

Angiogenesis - 5 Dec 2024

Tu Tianqi, Zhang Shikun, Li Jingwei, Jiang Chendan, Ren Jian, Zhang Shiju, Meng Xiaosheng, Peng Hao, Xing Dong, Zhang Hongqi, Hong Tao, Yu Jiaxing

Abstract excerpt

Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesions are thought to result from somatic KRAS/BRAF mutations in brain endothelial cells (bECs). In this study, we introduce a new bAVM model by inducing a brain endothelial-specific BrafV600E mutation using the Slc1o1c1(BAC)-CreER driver line. The pathological characteristics of this model...

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Identifiers

PMID: 39636449
DOI: 10.1007/s10456-024-09957-1

Genes

ANGPT2
BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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