Article
Gene variants rs5182, rs2074192, and rs4343 in the renin-angiotensin-aldosterone system are associated with symptom severity, higher odds of hospitalization, and death in COVID-19.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jul 2024
Martinez-Fierro Margarita L, Perez-Favila Aurelio, Zorrilla-Alfaro Sidere M, Oropeza-de Lara Sergio A, Garza-Veloz Idalia, Hernandez-Marquez Lucia Del S, Gutierrez-Vela Edgar F, Delgado-Enciso Ivan, Rodriguez-Sanchez Iram P
Abstract excerpt
OBJECTIVES: To analyze the gene variants of the renin-angiotensin-aldosterone system and determine their association with the severity and outcome of COVID-19. METHODS: A total of 104 patients were included in the study: 34 asymptomatic patients with COVID-19 as controls and 70 symptomatic patients as cases. The genetic variants ACE rs4343, ACE2 rs2074192, AGTR1 rs5182, and AGT rs4762 were identified using TaqMan...