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Article

SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease.

Virology journal - 19 Mar 2022

Alimoradi Nahid, Sharqi Moein, Firouzabadi Dena, Sadeghi Mohammad Moein, Moezzi Mohammad Iman, Firouzabadi Negar

Abstract excerpt

COVID-19 and the renin-angiotensin system (RAS) are linked by angiotensin-converting enzyme 2 (ACE2), a key enzyme in RAS that has been validated as a SARS-CoV-2 receptor. Functional ACE1/ACE2 gene polymorphisms may lead to the imbalance between ACE/ACE2 ratio and thus generating RAS imbalance that is associated with higher degrees of lung damage in ARDS that may contribute to the COVID-19 infection outcome....

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Identifiers

PMID: 35305693
DOI: 10.1186/s12985-022-01782-6
PMCID: PMC8934128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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