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Article

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome.

Gene - 15 Dec 2020

Gómez Juan, Albaiceta Guillermo M, García-Clemente Marta, López-Larrea Carlos, Amado-Rodríguez Laura, Lopez-Alonso Inés, Hermida Tamara, Enriquez Ana I, Herrero Pablo, Melón Santiago, Alvarez-Argüelles Marta E, Boga José A, Rojo-Alba Susana, Cuesta-Llavona Elías, Alvarez Victoria, Lorca Rebeca, Coto Eliecer

Abstract excerpt

The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the individuaĺs susceptibility to infection. In addition, the balance between ACE1 and ACE2 activity has been implicated in the pathogenesis of respiratory diseases and could play a role in the severity of COVID-19. Functional ACE1/ACE2 gene...

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Source

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Identifiers

PMID: 32882331
DOI: 10.1016/j.gene.2020.145102
PMCID: PMC7456966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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