Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease.

PloS one - 1 Jan 2022

Sabater Molina Maria, Nicolás Rocamora Elisa, Bendicho Asunción Iborra, Vázquez Elisa García, Zorio Esther, Rodriguez Fernando Domínguez, Gil Ortuño Cristina, Rodríguez Ana Isabel, Sánchez-López Antonio J, Jara Rubio Rubén, Moreno-Docón Antonio, Marcos Pedro J, García Pavía Pablo, Villa Roberto Barriales, Gimeno Blanes Juan R

Abstract excerpt

BACKGROUND: Infection by the SARS-Cov-2 virus produces in humans a disease of highly variable and unpredictable severity. The presence of frequent genetic single nucleotide polymorphisms (SNPs) in the population might lead to a greater susceptibility to infection or an exaggerated inflammatory response. SARS-CoV-2 requires the presence of the ACE2 protein to enter in the cell and ACE2 is a regulator of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Angiotensin-Converting Enzyme 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COVID-19

Share to Peptidyl-Dipeptidase A

Share to Polymorphism, Single Nucleotide

Share to Receptor, Angiotensin, Type 1

Share to SARS-CoV-2

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 35120165
DOI: 10.1371/journal.pone.0263140
PMCID: PMC8815985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease.PMID 35120165Read ↗

Association of ACE2 Gene Variants with the Severity of COVID-19 Disease-A Prospective Observational Study.Semantic proximity Read ↗

ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19.Semantic proximity Read ↗

ACE2 and TMPRSS2 SNPs as Determinants of Susceptibility to, and Severity of, a COVID-19 Infection.Semantic proximity Read ↗

Role of ACE, ACE2 gene variants and serum ACE/ACE2 ratio in COVID-19 severitySemantic proximity Read ↗

The Impact of ACE2 Polymorphisms on COVID-19 Disease: Susceptibility, Severity, and TherapySemantic proximity Read ↗

Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease MortalitySemantic proximity Read ↗

SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease.Semantic proximity Read ↗

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome.Semantic proximity Read ↗

Polymorphism of Angiotensin-Converting Enzyme 2 Gene (rs 2285666) and its susceptibility to COVID-19 infection and severity of the disease.Semantic proximity Read ↗

Variants in ACE2; potential influences on virus infection and COVID-19 severity.Semantic proximity Read ↗

Role of ACE2 and TMPRSS2 polymorphisms on COVID-19 outcome and disease severity in adult patients: A prospective cohort study in a tertiary hospital, Indonesia.Semantic proximity Read ↗

Angiotensin-converting enzyme 2 (ACE2) polymorphisms and susceptibility of severe SARS-CoV-2 in a subset of Pakistani population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.