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Article

Molecular functions of ANKLE2 and its implications in human disease.

Disease models & mechanisms - 1 Apr 2024

Fishburn Adam T, Florio Cole J, Lopez Nick J, Link Nichole L, Shah Priya S

Abstract excerpt

Ankyrin repeat and LEM domain-containing 2 (ANKLE2) is a scaffolding protein with established roles in cell division and development, the dysfunction of which is increasingly implicated in human disease. ANKLE2 regulates nuclear envelope disassembly at the onset of mitosis and its reassembly after chromosome segregation. ANKLE2 dysfunction is associated with abnormal nuclear morphology and cell division. It...

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Identifiers

PMID: 38691001
DOI: 10.1242/dmm.050554
PMCID: PMC11103583

Genes

BANF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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