Article
Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.
Developmental cell - 16 Dec 2019
Link Nichole, Chung Hyunglok, Jolly Angad, Withers Marjorie, Tepe Burak, Arenkiel Benjamin R, Shah Priya S, Krogan Nevan J, Aydin Hatip, Geckinli Bilgen B, Tos Tulay, Isikay Sedat, Tuysuz Beyhan, Mochida Ganesh H, Thomas Ajay X, Clark Robin D, Mirzaa Ghayda M, Lupski James R, Bellen Hugo J
Abstract excerpt
The apical Par complex, which contains atypical protein kinase C (aPKC), Bazooka (Par-3), and Par-6, is required for establishing polarity during asymmetric division of neuroblasts in Drosophila, and its activity depends on L(2)gl. We show that loss of Ankle2, a protein associated with microcephaly in humans and known to interact with Zika protein NS4A, reduces brain volume in flies and impacts the function of...
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