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Article

Frequency, underdiagnosis, and heterogeneity of epidermal growth factor receptor exon 20 insertion mutations using real-world genomic datasets.

Molecular oncology - 1 Feb 2023

Viteri Santiago, Minchom Anna, Bazhenova Lyudmila, Ou Sai-Hong Ignatius, Bauml Joshua M, Shell Scott A, Schaffer Michael, Gu Junchen, Rose Jennifer B, Curtin Joshua C, Mahadevia Parthiv, Girard Nicolas

Abstract excerpt

Epidermal growth factor receptor (EGFR) exon 20 insertion mutations (ex20ins) account for ≤ 12% of all EGFR-mutant nonsmall cell lung cancers. We analysed real-world datasets to determine the frequency of ex20ins variants, and the ability of polymerase chain reaction (PCR) and next-generation sequencing (NGS) to identify them. Three real-world United States NGS databases were used: GENIE, FoundationInsights, and...

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Identifiers

PMID: 36269676
DOI: 10.1002/1878-0261.13327
PMCID: PMC9892822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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