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Article

Distribution and Detectability of EGFR Exon 20 Insertion Variants in NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2023

Ou Sai-Hong Ignatius, Hong Jin-Liern, Christopoulos Petros, Lin Huamao M, Vincent Sylvie, Churchill Eric N, Soeda Junpei, Kazdal Daniel, Stenzinger Albrecht, Thomas Michael

Abstract excerpt

INTRODUCTION: EGFR exon 20 insertion (ex20ins) mutations represent 5% to 10% of EGFR mutations in NSCLC. Identifying patients with EGFR ex20ins is challenging owing to the limited coverage of polymerase chain reaction (PCR) assays and the relatively recent use of next-generation sequencing (NGS). This study analyzes the spectrum of EGFR ex20ins variants in a large patient population from a global clinical trial...

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PMID: 36738930
DOI: 10.1016/j.jtho.2023.01.086

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