Article
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
HGG advances - 18 Jul 2024
Marchal Astrid, Cirulli Elizabeth T, Neveux Iva, Bellos Evangelos, Thwaites Ryan S, Schiabor Barrett Kelly M, Zhang Yu, Nemes-Bokun Ivana, Kalinova Mariya, Catchpole Andrew, Tangye Stuart G, Spaan András N, Lack Justin B, Ghosn Jade, Burdet Charles, Gorochov Guy, Tubach Florence, Hausfater Pierre, Dalgard Clifton L, Zhang Shen-Ying, Zhang Qian, Chiu Christopher, Fellay Jacques, Grzymski Joseph J, Sancho-Shimizu Vanessa, Abel Laurent, Casanova Jean-Laurent, Cobat Aurélie, Bolze Alexandre
Abstract excerpt
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association...
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