A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.

doi:10.1038/s41586-023-06331-x

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Article

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.

Nature - 1 Aug 2023

Augusto Danillo G, Murdolo Lawton D, Chatzileontiadou Demetra S M, Sabatino Joseph J, Yusufali Tasneem, Peyser Noah D, Butcher Xochitl, Kizer Kerry, Guthrie Karoline, Murray Victoria W, Pae Vivian, Sarvadhavabhatla Sannidhi, Beltran Fiona, Gill Gurjot S, Lynch Kara L, Yun Cassandra, Maguire Colin T, Peluso Michael J, Hoh Rebecca, Henrich Timothy J, Deeks Steven G, Davidson Michelle, Lu Scott, Goldberg Sarah A, Kelly J Daniel, Martin Jeffrey N, Vierra-Green Cynthia A, Spellman Stephen R, Langton David J, Dewar-Oldis Michael J, Smith Corey, Barnard Peter J, Lee Sulggi, Marcus Gregory M, Olgin Jeffrey E, Pletcher Mark J, Maiers Martin, Gras Stephanie, Hollenbach Jill A

Abstract excerpt

Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic1-4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance. Here, postulating that variation in the human leukocyte antigen (HLA) loci may underly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37468623
DOI: 10.1038/s41586-023-06331-x
PMCID: PMC10396966

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