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Article

A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.

The Journal of allergy and clinical immunology - 1 Aug 2024

Risemberg Ellen L, Smeekens Johanna M, Cruz Cisneros Marta C, Hampton Brea K, Hock Pablo, Linnertz Colton L, Miller Darla R, Orgel Kelly, Shaw Ginger D, de Villena Fernando Pardo Manuel, Burks A Wesley, Valdar William, Kulis Michael D, Ferris Martin T

Abstract excerpt

BACKGROUND: The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized Collaborative Cross strain CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, in contrast to C3H/HeJ (C3H) mice. OBJECTIVE: This study aimed to determine the genetic basis of...

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Identifiers

PMID: 38670234
DOI: 10.1016/j.jaci.2024.03.027
PMCID: PMC11323216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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