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Article

Epithelial-mesenchymal interaction protects normal colonocytes from 4-HNE-induced phenotypic transformation.

PloS one - 1 Jan 2024

Dupuy Jacques, Cogo Emma, Fouché Edwin, Guéraud Françoise, Pierre Fabrice, Plaisancié Pascale

Abstract excerpt

INTRODUCTION: Recent studies have shown that epithelial-stromal interactions could play a role in the development of colorectal cancer. Here, we investigated the role of fibroblasts in the transformation of normal colonocytes induced by 4-HNE. METHODS: Normal Co colonocytes and nF fibroblasts from the same mouse colon were exposed, in monoculture (m) or coculture (c), to 4-HNE (5 μM) twice weekly for 3 weeks....

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Identifiers

PMID: 38669265
DOI: 10.1371/journal.pone.0302932
PMCID: PMC11051638

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BMP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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