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Article

Sit4 Genetically Interacts with Vps27 to Regulate Mitochondrial Function and Lifespan in Saccharomyces cerevisiae.

Cells - 9 Apr 2024

Martins Telma S, Correia Miguel, Pinheiro Denise, Lemos Carolina, Mendes Marta Vaz, Pereira Clara, Costa Vítor

Abstract excerpt

The Sit4 protein phosphatase plays a key role in orchestrating various cellular processes essential for maintaining cell viability during aging. We have previously shown that SIT4 deletion promotes vacuolar acidification, mitochondrial derepression, and oxidative stress resistance, increasing yeast chronological lifespan. In this study, we performed a proteomic analysis of isolated vacuoles and yeast genetic...

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Identifiers

PMID: 38667270
DOI: 10.3390/cells13080655
PMCID: PMC11049076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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