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Article

Genetic correlation between circulating cytokines and risk of three ophthalmic diseases: a bidirectional two-sample Mendelian randomization study.

Human molecular genetics - 6 Jul 2024

Zhang Xin, Fu Qiangqiang, Cai Yuying, Li Xianglian, Chen Li, Jiang Yaping, Chen Yihui

Abstract excerpt

PURPOSE: Pathogenesis and the associated risk factors of cataracts, glaucoma, and age-related macular degeneration (AMD) remain unclear. We aimed to investigate causal relationships between circulating cytokine levels and the development of these diseases. PATIENTS AND METHODS: Genetic instrumental variables for circulating cytokines were derived from a genome-wide association study of 8293 European participants....

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PMID: 38664229
DOI: 10.1093/hmg/ddae041

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