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Inflammatory cytokines are not associated with early age-related macular degeneration: a two-sample Mendelian randomisation study.

Eye (London, England) - 1 Apr 2026

Dai Yuanmin, Liang Guanlu, Xu Jiehui, Wang Juanjuan, Yang Chunbaixue

Abstract excerpt

BACKGROUND/OBJECTIVES: Observational research indicated a potential relationship between inflammatory cytokines and early age-related macular degeneration (AMD), but causal associations remain unclear. SUBJECTS/METHODS: Using summary data from genome-wide association studies (GWAS) of 41 different inflammatory cytokines and AMD (including early and late stages), we employed a two-sample Mendelian randomisation...

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Cytokines
ALK gene
Genome-Wide Association Study
Macular Degeneration
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 41559451
DOI: 10.1038/s41433-025-04225-y
PMCID: PMC13013951

Genes

ALK
F12
HTR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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