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Article

A mutation in the cardiac KV7.1 channel possibly disrupts interaction with Yotiao protein.

Biochemical and biophysical research communications - 25 Jun 2024

Li Bowen, Karlova Maria, Zhang Han, Pustovit Oksana B, Mai Lisha, Novoseletsky Valery, Podolyak Dmitry, Zaklyazminskaya Elena V, Abramochkin Denis V, Sokolova Olga S

Abstract excerpt

Here, we characterized the p.Arg583His (R583H) Kv7.1 mutation, identified in two unrelated families suffered from LQT syndrome. This mutation is located in the HС-HD linker of the cytoplasmic portion of the Kv7.1 channel. This linker, together with HD helix are responsible for binding the A-kinase anchoring protein 9 (AKAP9), Yotiao. We studied the electrophysiological characteristics of the mutated channel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38657442
DOI: 10.1016/j.bbrc.2024.149947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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