Article

Functional Evaluation of <i>TRPC6</i> Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Gain-of-function mutations in the transient receptor potential 6 (TRPC6) channel have recently been recognized as risk factors for both doxorubicin (DOX)-induced cardiomyopathy. Functional evaluation of TRPC6 missense variants is therefore important for cancer patients undergoing anthracycline treatment. However, traditional electrophysiological methods are labor-intensive and time-consuming. I...

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Literature Corpus work: 97adde6e-f041-5a9b-ae19-ff0d108773f1
DOI: 10.64898/2026.01.01.697223

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