Exploring hematological alterations and genetics linked to SNV rs10974944 in myeloproliferative neoplasms among Amazon patients.

doi:10.1038/s41598-024-60090-x

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Exploring hematological alterations and genetics linked to SNV rs10974944 in myeloproliferative neoplasms among Amazon patients.

Scientific reports - 24 Apr 2024

Paes Jhemerson F, Torres Dania G, Aquino Deborah C, Alves Emanuela V B, Mesquita Erycka A, Sousa Miliane A, Fraiji Nelson Abrahim, Passos Leny N M, Abreu Rosângela S, Silva George A V, Tarragô Andréa M, de Souza Mourão Lucivana P

Abstract excerpt

BCR::ABL1-negative myeloproliferative neoplasms are hematopoietic disorders characterized by panmyelosis. JAK2 V617F is a frequent variant in these diseases and often occurs in the 46/1 haplotype. The G allele of rs10974944 has been shown to be associated with this variant, specifically its acquisition, correlations with familial cases, and laboratory alterations. This study evaluated the association between the...

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PMID: 38654055
DOI: 10.1038/s41598-024-60090-x
PMCID: PMC11039700

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Exploring hematological alterations and genetics linked to SNV rs10974944 in myeloproliferative neoplasms among Amazon patients.PMID 38654055Read ↗

Hematological alterations associated with the SNV rs10974944, part of the 46/1 haplotype, in patients from the Brazilian Amazon with BCR::ABL1-negative myeloproliferative neoplasmsSemantic proximity Read ↗

JAK2 46/1 haplotype is associated with JAK2 V617F--positive myeloproliferative neoplasms in Brazilian patients.Semantic proximity Read ↗

The G allele of the JAK2 rs10974944 SNP, part of JAK2 46/1 haplotype, is strongly associated with JAK2 V617F-positive myeloproliferative neoplasms.Semantic proximity Read ↗

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