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Article

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania.

Scientific reports - 23 Apr 2024

Hiza Hellen, Zwyer Michaela, Hella Jerry, Arbués Ainhoa, Sasamalo Mohamed, Borrell Sonia, Xu Zhi Ming, Ross Amanda, Brites Daniela, Fellay Jacques, Reither Klaus, Gagneux Sébastien, Portevin Damien

Abstract excerpt

The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aimed to assess if bacterial genetics governs MTBC pathogenesis or if local co-adaptation translates into differential susceptibility of human macrophages to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38653771
DOI: 10.1038/s41598-024-60001-0
PMCID: PMC11039734

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