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Advancing triage of acute lymphoblastic leukaemia subtypes diagnosis: label-free Raman spectroscopy for precise single-cell phenotyping and subtype classification.

The Analyst - 4 Nov 2024

Leszczenko Patrycja, Nowakowska Anna M, Dawiec Patrycja, Czuja Karolina, Jakubowska Justyna, Zabczynska Marta, Pastorczak Agata, Ostrowska Kinga, Tott Szymon, Mlynarski Wojciech, Baranska Malgorzata, Majzner Katarzyna

Abstract excerpt

Acute lymphoblastic leukaemia (ALL) is a complex disease in pediatric oncology, necessitating accurate diagnostic strategies for effective treatment planning. The ability to differentiate between B-cell ALL (B-ALL) and T-cell ALL (T-ALL) is crucial for targeted interventions. However, current diagnostic methods are time-consuming and require rapid, dependable tests. This study explores the potential of label-free...

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PMID: 39390798
DOI: 10.1039/d4an00956h

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