Article
Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases.
Current opinion in clinical nutrition and metabolic care - 1 Jul 2017
Lamas Bruno, Richard Mathias L, Sokol Harry
Abstract excerpt
PURPOSE OF REVIEW: Inflammatory bowel diseases (IBDs) develop as a result of a combination of genetic predisposition, dysbiosis of the gut microbiota, and environmental influences. Here, we describe an example of how caspase recruitment domain 9 (CARD9), one of the numerous IBD susceptibility genes, participate to colitis susceptibility by shaping gut microbiota to produce tryptophan metabolites. RECENT FINDINGS:...
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