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Article

Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence.

Gut - 1 Oct 2018

Lamas Bruno, Michel Marie-Laure, Waldschmitt Nadine, Pham Hang-Phuong, Zacharioudaki Vassiliki, Dupraz Louise, Delacre Myriam, Natividad Jane M, Costa Gregory Da, Planchais Julien, Sovran Bruno, Bridonneau Chantal, Six Adrien, Langella Philippe, Richard Mathias L, Chamaillard Mathias, Sokol Harry

Abstract excerpt

OBJECTIVE: In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9-/- mice are more susceptible to the enteric mouse pathogen Citrobacter rodentium that mimics human infections with enteropathogenic and enterohaemorrhagic...

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Source

Identifiers

PMID: 28790160
DOI: 10.1136/gutjnl-2017-314195

Genes

CARD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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