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T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets

22 Apr 2024

Abstract excerpt

BACKGROUND: Immune cell infiltration is heterogeneous but common in testicular germ cell tumors (TGCT) and pre-invasive germ cell neoplasia in situ (GCNIS). Tumor-infiltrating T cells including regulatory T (Treg) and follicular helper T (Tfh) cells are found in other cancer entities, but their contributions to TGCT are unknown. METHODS: Human testis specimens from independent patient cohorts were analyzed using...

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PMID: 38649788
DOI: 10.1038/s41416-024-02669-9

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