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CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection

28 Mar 2025

Abstract excerpt

With the broad spread of the chikungunya virus (CHIKV), there is an increasing demand for more effective and broadly protective vaccines. Here, we designed CHIKV mRNA vaccines containing full-length structural proteins or part of structural proteins (envelope proteins) based on conserved sequences from 769 viral strains encompassing four lineages. The vaccine induced strong cellular and humoral immune responses...

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PMID: 40148284
DOI: 10.1038/s41392-025-02182-2

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