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Random forests algorithm boosts genetic risk prediction of systemic lupus erythematosus

15 Aug 2022

Abstract excerpt

Patients with systemic lupus erythematosus (SLE) present varied clinical manifestations, posing a diagnostic challenge for physicians. Genetic factors substantially contribute to SLE development. A polygenic risk scoring (PRS) model has been used to estimate the genetic risk of SLE in individuals. However, this approach assumes independent and additive contribution of genetic variants to disease development. We...

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PMID: 36046232
DOI: 10.3389/fgene.2022.902793

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