Article
A survey of the population genetic variation in the human kinome.
Journal of human genetics - 1 Aug 2009
Zhang Wei, Catenacci Daniel V T, Duan Shiwei, Ratain Mark J
Abstract excerpt
Protein kinases are key regulators of various biological processes, such as control of cell growth, metabolism, differentiation and apoptosis. Therefore, protein kinases have been an important class of targets for anticancer drugs. Health-related disparities such as differential drug response have been observed between human populations. A survey of the human kinases and their ligand genes for those containing...
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