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Article

Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.

JAMA oncology - 1 Nov 2017

Yap Yoon-Sim, Kwok Li-Lian, Syn Nicholas, Chay Wen Yee, Chia John Whay Kuang, Tham Chee Kian, Wong Nan Soon, Lo Soo Kien, Dent Rebecca Alexandra, Tan Sili, Mok Zuan Yu, Koh King Xin, Toh Han Chong, Koo Wen Hsin, Loh Marie, Ng Raymond Chee Hui, Choo Su Pin, Soong Richie Chuan Teck

Abstract excerpt

IMPORTANCE: Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment. OBJECTIVE: To compare the incidence and time to onset of grade 2 or greater HFS in patients receiving pyridoxine vs placebo and to identify biomarkers predictive of HFS. DESIGN, SETTING, AND PARTICIPANTS: This single-center, randomized double-blind, placebo-controlled phase 3 trial conducted at National Cancer Centre...

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Source

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Identifiers

PMID: 28715540
DOI: 10.1001/jamaoncol.2017.1269
PMCID: PMC5710192

Genes

DPYD
MACF1
SPRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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