Article
[A mice model of amyotrophic lateral sclerosis expressing mutant human FUS protein].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2014
Deĭkin A V, Kovrazhkina E A, Ovchinnikov R K, Bronovitskiĭ E V, Razinskaia O D, Smirnov A P, Ermolkevich T G, Eliakov A B, Popov A N, Fedorov E N, Lytkina O A, Kukharskiĭ M S, Tarasova T V, Shelkovnikova T A, Ustiugov A A, Ninkina N N, Gol'dman I L, Sadchikova E R, Bachurin S O, Skvortsova V I
Abstract excerpt
UNLABELLED: BACKGROUND AND ОBJECTIVE: Loss of conformation and function of sufficient number of proteins with high aggregation capacity plays an important role in the pathogenesis of many neurodegenerative disorders (NDD). Due to a recent discovery of new array of proteins with the capacity to form aggregates of nonamyloid type, new NDD models as well as a new level of understanding in vivo models which are...
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