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Structural mechanism underlying variations in DNA binding by the androgen receptor

10 Apr 2024

Abstract excerpt

The androgen receptor (AR) is a steroid activated transcription factor which recognizes DNA motifs resembling inverted repeats of a conserved 5'-AGAACA-3'-like hexanucleotides separated by a three-nucleotide spacer from a similar, but less conserved hexanucleotide. Here, we report the structures of the human AR DNA binding domain (DBD) bound to two natural AREs (C3 and MTV) in head-to-head dimer conformations,...

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PMID: 38604378
DOI: 10.1016/j.jsbmb.2024.106499

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